Tissue Engineering Posted Monday, February 18, 2002 by ctustis
A leading surgeon in the US has told BBC News that he is ready to perform
the world's first transplant of an artificially grown organ.

Dr Anthony Atala, of the Boston Children's Hospital, says he hopes to put
a laboratory-engineered bladder into a patient once he has obtained the
necessary regulatory approval.

He believes permission for the procedure, which has been pioneered in
dogs, will come within the next few months.

Dr Attalla says that if he is successful with the bladder transplant, he
will attempt to repair damaged hearts with new muscle and possibly even
try to grow a kidney.

Polymer ball

"I think over time there will be no limit," Dr Atala said. "I think it is
just a question of figuring out all the different tissue types and cell
types and how they work best, but eventually I think that following the
same strategies just about every organ in the body will be repairable at
the very least."

It was exactly two years ago that a team from the Laboratory for Tissue
Engineering at the Children's Hospital and Harvard Medical School in
Boston announced that it had successfully implanted six beagle dogs with
lab-grown bladders.

Tissue samples were taken from the animals' original bladders and these
were used to cultivate the muscle cells and special bladder skin cells,
called urothelial cells, needed to construct the artificial organs.

The multiplying cells were shaped into beagle bladders by bedding them
down over polymer balls. Transplanted into the dogs, these lab-grown
organs allowed the animals to urinate normally.

Important ally

Dr Atala believes his technique is sufficiently well developed that it
could be used to treat a young child.

A lab-grown bladder could be the answer for a patient whose own organ has
been destroyed by cancer or damaged by an infection or injury.

Dr Atala is seeking approval for human trials from the US Food and Drug
Administration.

Although tissue engineering has huge potential, Dr Atala believes there
will always be a need for donor organs. "I think tissue engineering is
just another solution but it should help reduce the number of patients on
a transplant list."

And, he believes, tissue engineering will prove to be a useful ally to
the emerging field of stem cell medicine, in which "young" cells are
injected into ailing tissue to regenerate it.

"For example, with a patient who has a failing heart, where obviously it
would be very hard to get a biopsy because they would not tolerate the
procedure; then I think stem cells would be the ideal answer."

This is the entire article from
http://news.bbc.co.uk/hi/english/in_depth/sci_tech/2002/boston_2002/newsid_1821000/1821440.stm